Case study
Containing the GLP-1 SPSS manufacturing processes with Downflow Booths and Kilohoods
Posted:
Challenge
The manufacturing process of GLP-1 analogs involves hazardous steps, particularly during solid-phase peptide Synthesis (SPPS) and purification. This process utilizes various toxic and potentially carcinogenic chemicals, including trifluoroacetic acid, dimethylformamide, dichloromethane, and coupling reagents with OEB requirements of 3 & 4 and PPM exposures less than 1 ppm.
Manufacturers are continuously enhancing safety measures to manufacture these compounds safely while meeting the growing global demand for these life-changing GLP-1 injectables. Howorths standard product range is the answer to help maintain these needs
Solution
Howorth'sWorkSAFE Downflow Booths and KiloHOOD products are designed to achieve containment levels suitable for OEB 3 & 4 and maintaining exposure below <1ppm.
Howorth Downflow Booths utilize a unidirectional airflow system, where air is passed through ceiling-mounted H14 HEPA filters to ensure a controlled environment.T his filtered air is directed to carry contaminants away from the operator's breathing zone, flowing into low-level exhaust grilles and through the booth’s safe change HEPA filtration system. If solvents are present, the airflow system can be single-pass pass designed to protect the working environment.
During the purification process, where containment levels of <1 ppm are critical due to the exposure risks posed by toxic vapors, Kilohoods are essential. Howorth's Kilohoods provide a safe environment for these sensitive processes. With a continuous inrush of air through open doors, combined with a High Containment Screen, our technology ensures a highly controlled atmosphere, meeting stringent safety and containment requirements
Outcome
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